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Research Projects Requiring IBC Registration
Experiments that Must be Registered &
Approved PRIOR to Initiation:
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Cloning of DNA encoding molecules toxic to vertebrates within
LD50<100ng/kg body weight.
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Cloning of total DNA from all Class 2, 3, or 4 human or animal pathogens
(including HIV and related viruses, and human tumor viruses).
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Experiments using as vectors more than two-thirds of the genome of infectious animal or plant
viruses or defective recombinant viruses grown in the presence of a helper virus.
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Experiments using as vectors more than two-thirds of the genome of infectious
animal or plant viruses or defective recombinant viruses grown in the presence
of a helper virus.
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Cloning using human or animal pathogens as host-vector systems.
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All experiments that may generate transgenic animals requiring BL-1 containment;
- This includes rodents
constructed, purchased or transferred, or plants which may extend the host-range of human,
or animal pathogen that require BL-2 or greater containment.
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All human gene transfer experiments.
- Experiments involving whole plants.
Experiments that Require Registration SIMULTANEOUS with Initiation:
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Experiments using as vectors less than two-thirds of the genome of defective
animal or plant viruses, free of helper virus.
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Cloning of DNA for more than one-half of the genome of Class 1 or Class 2 human
or animal pathogens, or cloning of known oncogenes.
- All experiments that may be constructed, purchased or transferred transgenic rodents at BL-1 containment.
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